Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration.

ABSTRACT: Individual differences in response to social stress and environmental enrichment may contribute to variability in response to behavioral and pharmacological treatments for drug addiction. In monkeys, social status influences the reinforcing effects of cocaine and the effects of some drugs on cocaine self-administration. In this study, we used male cynomolgus macaques (n=15) living in established social groups to examine the effects of social confrontation on the reinforcing effects of cocaine using a food-drug choice procedure. On the test day, a dominant or subordinate monkey was removed from his homecage and placed into another social pen; 30 min later he was studied in a cocaine-food choice paradigm. For the group, following social confrontation, sensitivity to cocaine reinforcement was

SUBMITTER: Gould RW 

PROVIDER: S-EPMC5506801 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature