Intra-operative multi-site stimulation: Expanding methodology for cortical brain mapping of language functions.

ABSTRACT: Direct cortical stimulation (DCS) is considered the gold-standard for functional cortical mapping during awake surgery for brain tumor resection. DCS is performed by stimulating one local cortical area at a time. We present a feasibility study using an intra-operative technique aimed at improving our ability to map brain functions which rely on activity in distributed cortical regions. Following standard DCS, Multi-Site Stimulation (MSS) was performed in 15 patients by applying simultaneous cortical stimulations at multiple locations. Language functioning was chosen as a case-cognitive domain due to its relatively well-known cortical organization. MSS, performed at sites that did not produce disruption when applied in a single stimulation point, revealed additional language dysfunction in

SUBMITTER: Gonen T 

PROVIDER: S-EPMC5507257 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature