Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations.

ABSTRACT:

Aim

We hypothesised that some of the genetic risk for gestational diabetes (GDM) is due to the fetal genome affecting maternal glucose concentrations. Previously, we found associations between fetal IGF2 gene variants and maternal glucose concentrations in late pregnancy.

Methods

In the present study, we tested associations between SNP alleles from 15 fetal imprinted genes and maternal glucose concentrations in late pregnancy in the Cambridge Baby Growth and Wellbeing cohorts (1160 DNA trios).

Results

Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10^-4) and INS rs2585 (P-value=7×10^-4), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value=1×10^-3) and KCNQ1(OT1) rs7

SUBMITTER: Petry CJ 

PROVIDER: S-EPMC5507297 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature