Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.

ABSTRACT:

Objective

To examine the association of bradykinin and related peptides with the development of diabetic nephropathy lesions in 243 participants with type 1 diabetes (T1D) from the Renin-Angiotensin System Study who, at baseline, were normoalbuminuric, normotensive and had normal or increased glomerular filtration rate (GFR).

Design

Plasma concentrations of bradykinin and related peptides were measured at baseline by quantitative mass spectrometry. All participants were randomly assigned at baseline to receive placebo, enalapril or losartan during the 5 years between kidney biopsies. Kidney morphometric data were available from kidney biopsies at baseline and after 5 years. Relationships of peptides with changes in morphometric variables were assessed using multiple linear r

SUBMITTER: Wheelock KM 

PROVIDER: S-EPMC5507314 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature