Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.

ABSTRACT: Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to drug resistance. Given that the genetic architecture of resistance is poorly understood for any nematode, we have analyzed multidrug resistant Teladorsagia circumcincta, a major parasite of sheep, as a model for analysis of resistance selection. We introgressed a field-derived multiresistant genotype into a partially inbred susceptible genetic background (through repeated backcrossing and drug selection) and performed genome-wide scans in the backcross progeny and drug-selected F2 populations to identify the major genes responsible for the m

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC5507320 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature