Clinical Relevance and Role of Neuronal AT₁ Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.

ABSTRACT:

Rationale

Neurogenic hypertension is characterized by an increase in sympathetic activity and often resistance to drug treatments. We previously reported that it is also associated with a reduction of angiotensin-converting enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in experimental hypertension. In addition, while multiple cells within the central nervous system have been involved in the development of neurogenic hypertension, the contribution of ADAM17 has not been investigated.

Objective

To assess the clinical relevance of this ADAM17-mediated ACE2 shedding in hypertensive patients and further identify the cell types and signaling pathways involved in this process.

Methods and results

Using a mass spectrometry-base

SUBMITTER: Xu J 

PROVIDER: S-EPMC5507353 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature