Hierarchical patterning modes orchestrate hair follicle morphogenesis.

ABSTRACT: Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction-diffusion system posits that interacting diffusible signals produced by static cells first define a prepattern that then induces cell rearrangements to produce an anatomical structure. The second theory, that of mesenchymal self-organisation, proposes that mobile cells can form periodic patterns of cell aggregates directly, without reference to any prepattern. Early hair follicle development is characterised by the rapid appearance of periodic arrangements of altered gene expression in the epidermis and prominent clustering of the adjacent dermal mesenchymal cells. We assess the contributions and interplay between reaction-diffusion and m

SUBMITTER: Glover JD 

PROVIDER: S-EPMC5507405 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature