Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein.

ABSTRACT:

Objective

We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA.

Methods

The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated.

Results

SUBMITTER: Huang CM 

PROVIDER: S-EPMC5507450 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature