Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.

ABSTRACT: Parasitic diseases caused by kinetoplastid parasites of the genera Trypanosoma and Leishmania are an urgent public health crisis in the developing world. These closely related species possess a number of multimeric enzymes in highly conserved pathways involved in vital functions, such as redox homeostasis and nucleotide synthesis. Computational alanine scanning of these protein-protein interfaces has revealed a host of potentially ligandable sites on several established and emerging anti-parasitic drug targets. Analysis of interfaces with multiple clustered hotspots has suggested several potentially inhibitable protein-protein interactions that may have been overlooked by previous large-scale analyses focusing solely on secondary structure. These protein-protein interactions provide a prom

SUBMITTER: Wachsmuth LM 

PROVIDER: S-EPMC5507555 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature