Comprehensive Genomic Profiling of Esthesioneuroblastoma Reveals Additional Treatment Options.

ABSTRACT:

Background

Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant neoplasm of the olfactory mucosa. Despite surgical resection combined with radiotherapy and adjuvant chemotherapy, ENB often relapses with rapid progression. Current multimodality, nontargeted therapy for relapsed ENB is of limited clinical benefit.

Materials and methods

We queried whether comprehensive genomic profiling (CGP) of relapsed or refractory ENB can uncover genomic alterations (GA) that could identify potential targeted therapies for these patients. CGP was performed on formalin-fixed, paraffin-embedded sections from 41 consecutive clinical cases of ENBs using a hybrid-capture, adaptor ligation based next-generation sequencing assay to a mean coverage depth of 593X.

SUBMITTER: Gay LM 

PROVIDER: S-EPMC5507647 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature