Microsurgery guided by sequential preoperative lymphography using ⁶⁸Ga-NEB PET and MRI in patients with lower-limb lymphedema.

ABSTRACT:

Objective

The popularity of contemporary microsurgical techniques in treatment of lower-limb lymphedema calls for better visualization of the lymphatic system, both preoperatively and intra-operatively. The aim of this prospective study was to investigate the feasibility of a novel combination of ⁶⁸Ga-NEB positron emission tomography (PET) with magnetic resonance lymphography (MRL) in evaluating lymphedema and guiding surgical intervention.

Methods

A total of 11 patients (F 9, M 2, age range 29-69 y) with lower-limb lymphedema classified into stage I to III were recruited. PET acquisition was performed at 30, 60 and 90 min after subcutaneous injection of the albumin-binding radiotracer ⁶⁸Ga-NEB into the bilateral first web spaces of the feet. All the pa

SUBMITTER: Long X 

PROVIDER: S-EPMC5507721 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature