Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.

ABSTRACT:

Purpose

Exposure of the general population to ionizing radiation has increased in the past decades, primarily due to long distance travel and medical procedures. On the other hand, accidental exposures, nuclear accidents, and elevated threats of terrorism with the potential detonation of a radiological dispersal device or improvised nuclear device in a major city, all have led to increased needs for rapid biodosimetry and assessment of exposure to different radiation qualities and scenarios. Metabolomics, the qualitative and quantitative assessment of small molecules in a given biological specimen, has emerged as a promising technology to allow for rapid determination of an individual's exposure level and metabolic phenotype. Advancements in mass spectrometry techniques have led to

SUBMITTER: Pannkuk EL 

PROVIDER: S-EPMC5507746 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature