A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.

ABSTRACT:

Purpose

To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme.

Methods

The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K^trans ; intravascular plasma fraction, v_p ) cannot be individually separated and solves for a single parameter (k^vasc ) that quantifies the T₁ -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion. Untreated C6 tumor-bearing animals (N = 6) were serially imaged on postoperative days (PODs) 14 and 18 with a 3 Tesla clinical scanner utilizing a dynamic spatial and temporal resolution of 0.38 × 0.38 × 1.5 mm<

SUBMITTER: Underhill HR 

PROVIDER: S-EPMC5507763 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature