Associations between gene expression profiles of invasive breast cancer and Breast Imaging Reporting and Data System MRI lexicon.

ABSTRACT:

Purpose

To evaluate whether the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon could reflect the genomic information of breast cancers and to suggest intuitive imaging features as biomarkers.

Methods

Matched breast MRI data from The Cancer Imaging Archive and gene expression profile from The Cancer Genome Atlas of 70 invasive breast cancers were analyzed. Magnetic resonance images were reviewed according to the BI-RADS MRI lexicon of mass morphology. The cancers were divided into 2 groups of gene clustering by gene set enrichment an alysis. Clinicopathologic and imaging characteristics were compared between the 2 groups.

Results

The luminal subtype was predominant in the group 1 gene set and the triple-negative subtype was predominant in the group 2 ge

SUBMITTER: Kim GR 

PROVIDER: S-EPMC5507787 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature