Genotype by random environmental interactions gives an advantage to non-favored minor alleles.

ABSTRACT: Fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. Here we use a number of models (several versions of the Moran model and the haploid Wright-Fisher model) to examine fixation probabilities for a constant size population where the fitness is a random function of both allelic state and spatial position, despite neither allele being favored on average. The concept of fitness varying with respect to both genotype and environment is important in models of cancer initiation and progression, bacterial dynamics, and drug resistance. Under our model spatial heterogeneity redefines the notion of neutrality for a newly arising mutation, as such mutations fix at a higher

SUBMITTER: Mahdipour-Shirayeh A 

PROVIDER: S-EPMC5507875 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature