Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains.

ABSTRACT: Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vacci

SUBMITTER: Plant EP 

PROVIDER: S-EPMC5507920 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature