HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington's Disease.

ABSTRACT: Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as microarrays and mass-spectrometry has indicated multiple pathogenic routes. The massive data generated by these techniques together with the complexity of the pathogenesis, however, pose considerable challenges to researchers. Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. To facilitate research on HD in a network-oriented manner, we have developed HDN

SUBMITTER: Kalathur RKR 

PROVIDER: S-EPMC5507972 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature