Genetic Variants and Anterior Cruciate Ligament Rupture: A Systematic Review.

ABSTRACT:

Background

Studies have shown a familial predisposition for anterior cruciate ligament (ACL) rupture and have been followed by genetic-association studies on polymorphisms in candidate genes in recent years. To date, no systematic review with a best-evidence synthesis has evaluated the influence of genetics on this devastating knee injury.

Objective

Our objective was to evaluate the association between genetic variants and ACL rupture.

Methods

We performed an extensive search in Embase, MEDLINE, Web of Science, Scopus, PubMed Publisher, Cochrane Register of Clinical Trials, and Google scholar up to 24 August 2015. Studies were eligible if they met the following inclusion criteria: (1) design was a case-control study, retrospective or prospective follow-up study, or a

SUBMITTER: Kaynak M 

PROVIDER: S-EPMC5507974 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature