Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering.

ABSTRACT: Inflammatory microenvironment causes the change of epigenetic modification in periodontal ligament stem cells derived from periodontitis tissues (P-PDLSCs), which results in defective osteogenic differentiation compared to cells from healthy tissues. It's urgent to explore therapeutic strategies aimed at epigenetic targets associated with the regenerative ability of PDLSCs. Osthole, a small-molecule compound extracted from Chinese herbs, has been documented to promote osteogenesis and cell sheets formation of healthy PDLSCs. However, whether osthole shows same effect on P-PDLSCs and the mechanism of promotive effect is still unknown. The purpose of this study was to determine whether Osthole could restore defective osteogenic differentiation of P-PDLSCs via epigenetic modification. We demo

SUBMITTER: Sun J 

PROVIDER: S-EPMC5507976 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature