The impact of non-genetic and genetic factors on a stable warfarin dose in Thai patients.

ABSTRACT:

Purpose

The aim of this study was to investigate the contributions of non-genetic and genetic factors on the variability of stable warfarin doses in Thai patients.

Methods

A total of 250 Thai patients with stable warfarin doses were enrolled in the study. Demographics and clinical data, e.g., age, body mass index, indications for warfarin and concomitant medications, were documented. Four single nucleotide polymorphisms in the VKORC1 - 1639G > A, CYP2C9*3, CYP4F2 rs2108622, and UGT1A1 rs887829 genes were detected from gDNA using TaqMan allelic discrimination assays.

Results

The patients with variant genotypes of VKORC1 - 1639G > A required significantly lower warfarin stable weekly doses (SWDs) than those with wild-type genotype (p < 0.001). Similarly, the patients wi

SUBMITTER: Wattanachai N 

PROVIDER: S-EPMC5508045 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature