Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5508227 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature communications 20170711
The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 ...[more]