KCTD12 modulation of GABA(B) receptor function.

ABSTRACT: The molecular composition and functional diversity of native GABA_B receptors (GABA_BR) are still poorly understood, thus hindering development of selective GABA_BR ligands. Potassium channel tetramerization domain-containing protein (KCTD) 12 is a GABA_BR auxiliary subunit and mouse KCTD12 can alter GABA_BR function. In this study, we sought to characterize the effects of human KCTD12 on GABA_BR kinetics and pharmacology, using an automated electrophysiological assay. Seizure susceptibility and ethanol consumption were also investigated in a KCTD12 knockout mouse model. Human KCTD12 co-expression altered the kinetics of GABA_BR-mediated GIRK channels, speeding rates of both activation and desensitization. Analysis of co

SUBMITTER: Li M 

PROVIDER: S-EPMC5508304 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature