Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers.

ABSTRACT:

Background

Biochemical indicators for diagnosing liver disease are plasma alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), and bile acid concentration (BA).

Objectives

To determine the sensitivity and specificity of ALT, ALP, and BA for detecting primary hepatitis (PH) in clinically healthy Labrador retrievers and investigate whether ALT and ALP can discriminate between dogs with PH and nonspecific reactive hepatitis (RH).

Animals

191 clinically healthy and 51 clinically ill Labrador retrievers with hepatic histopathology.

Methods

Retrospective study. Medical records were reviewed for ALT, ALP, preprandial BA, liver histopathology, and hepatic copper concentrations.

Results

In 64% (122/191) of the clinically healthy Labrador

SUBMITTER: Dirksen K 

PROVIDER: S-EPMC5508325 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature