Porphyromonas gingivalis suppresses invasion of Fusobacterium nucleatum into gingival epithelial cells.

ABSTRACT: Invasion of periodontal pathogens into periodontal tissues is an important step that can cause tissue destruction in periodontal diseases. Porphyromonas gingivalis is a keystone pathogen and its gingipains are key virulence factors. Fusobacterium nucleatum is a bridge organism that mediates coadhesion of disease-causing late colonizers such as P. gingivalis and early colonizers during the development of dental biofilms. The aim of this study was to investigate how P. gingivalis, in particular its gingipains, influences the invasion of coinfecting F. nucleatum into gingival epithelial cells. When invasion of F. nucleatum was analyzed after 4 h of infection, invasion of F. nucleatum was suppressed in the presence of P. gingivalis compar

SUBMITTER: Jung YJ 

PROVIDER: S-EPMC5508355 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature