Genetics of Hereditary Ataxia in Scottish Terriers.

ABSTRACT:

Background

Scottish Terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex and causing slowly progressive cerebellar dysfunction.

Objective

To identify chromosomal regions associated with hereditary ataxia in Scottish Terriers.

Animals

One hundred and fifty-three Scottish Terriers were recruited through the Scottish Terrier Club of America.

Materials and methods

Prospective study. Dogs were classified as affected if they had slowly progressive cerebellar signs. When possible, magnetic resonance imaging and histopathological evaluation of the brain were completed as diagnostic aids. To identify genomic regions connected with the disease, genome-wide mapping was performed using both link

SUBMITTER: Urkasemsin G 

PROVIDER: S-EPMC5508367 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature