The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.

ABSTRACT: In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional changes that occur during retinogenesis in mice and humans. Although some progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most dramatic change was derepression of cell-type-specific differentiation programs. We identified developmental-stage-specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice. To determine how the epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent stem cells (iPSCs) derived from murine rod photor

SUBMITTER: Aldiri I 

PROVIDER: S-EPMC5508517 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature