NucDiff: in-depth characterization and annotation of differences between two sets of DNA sequences.

ABSTRACT:

Background

Comparing sets of sequences is a situation frequently encountered in bioinformatics, examples being comparing an assembly to a reference genome, or two genomes to each other. The purpose of the comparison is usually to find where the two sets differ, e.g. to find where a subsequence is repeated or deleted, or where insertions have been introduced. Such comparisons can be done using whole-genome alignments. Several tools for making such alignments exist, but none of them 1) provides detailed information about the types and locations of all differences between the two sets of sequences, 2) enables visualisation of alignment results at different levels of detail, and 3) carefully takes genomic repeats into consideration.

Results

We here present NucDiff, a tool aimed

SUBMITTER: Khelik K 

PROVIDER: S-EPMC5508607 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature