Phenotypic and genomic comparison of Mycobacterium aurum and surrogate model species to Mycobacterium tuberculosis: implications for drug discovery.

ABSTRACT:

Background

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and represents one of the major challenges facing drug discovery initiatives worldwide. The considerable rise in bacterial drug resistance in recent years has led to the need of new drugs and drug regimens. Model systems are regularly used to speed-up the drug discovery process and circumvent biosafety issues associated with manipulating M. tuberculosis. These include the use of strains such as Mycobacterium smegmatis and Mycobacterium marinum that can be handled in biosafety level 2 facilities, making high-throughput screening feasible. However, each of these model species have their own limitations.

Results

We report and describe the first complete genome sequence of Mycobacterium aurum ATCC23366, an envi

SUBMITTER: Namouchi A 

PROVIDER: S-EPMC5508667 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature