Physiological roles of sigma factor SigD in Corynebacterium glutamicum.

ABSTRACT:

Background

Sigma factors are one of the components of RNA polymerase holoenzymes, and an essential factor of transcription initiation in bacteria. Corynebacterium glutamicum possesses seven genes coding for sigma factors, most of which have been studied to some detail; however, the role of SigD in transcriptional regulation in C. glutamicum has been mostly unknown.

Results

In this work, pleiotropic effects of sigD overexpression at the level of phenotype, transcripts, proteins and metabolites were investigated. Overexpression of sigD decreased the growth rate of C. glutamicum cultures, and induced several physiological effects such as reduced culture foaming, turbid supernatant and cell aggregation. Upon overexpression of sigD, the level of Cmt1 (corynomycolyl transferase) i

SUBMITTER: Taniguchi H 

PROVIDER: S-EPMC5508688 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature