Individuals hospitalized with acute mania have increased exposure to antimicrobial medications.

ABSTRACT:

Objectives

We have preciously documented that many individuals with acute mania have immune activation. However, the sources of immune activation have not been identified. We investigated whether individuals hospitalized with acute mania have evidence of bacterial infections as determined by the prescription of systemic antimicrobial agents.

Methods

We assessed the recent prescription of systemic antimicrobial medications and the site of presumed bacterial infection in 234 individuals hospitalized for acute mania in either an inpatient unit or a day hospital. We also assessed individuals hospitalized for other psychiatric disorders (n=368) and controls (n=555). We employed logistic regression models to compare the rates of antibiotic prescription in individuals with the diff

SUBMITTER: Yolken R 

PROVIDER: S-EPMC5508736 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature