Tis11 mediated mRNA decay promotes the reacquisition of Drosophila intestinal stem cell quiescence.

ABSTRACT: Adult stem cell proliferation rates are precisely regulated to maintain long-term tissue homeostasis. Defects in the mechanisms controlling stem cell proliferation result in impaired regeneration and hyperproliferative diseases. Many stem cell populations increase proliferation in response to tissue damage and reacquire basal proliferation rates after tissue repair is completed. Although proliferative signals have been extensively studied, much less is known about the molecular mechanisms that restore stem cell quiescence. Here we show that Tis11, an Adenine-uridine Rich Element (ARE) binding protein that promotes mRNA degradation, is required to re-establish basal proliferation rates of adult Drosophila intestinal stem cells (ISC) after a regenerative episode. We find that Tis11 limits IS

SUBMITTER: McClelland L 

PROVIDER: S-EPMC5508743 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature