Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls.

ABSTRACT:

Background

Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the disease, functional analysis and mechanistic insights are generally lacking. We performed temporal bacterial (n = 613) and metabolomic (n = 63) profiling on extensively sampled stool from 7 infants with LOS and 28 matched healthy (no LOS or NEC) controls.

Results

The bacteria isolated in diagnostic blood culture usually corresponded to the dominant bacterial genera in the gut microbiome. Longitudinal changes were monitored based on preterm gut community types (PGCTs), where control infants had an increased number of PGCTs compared to LOS infants (P = 0.011). PGCT 6, characterised by Bifidobacteria do

SUBMITTER: Stewart CJ 

PROVIDER: S-EPMC5508794 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature