Sexual network drivers of HIV and herpes simplex virus type 2 transmission.

ABSTRACT:

Objectives

HIV and herpes simplex virus type 2 (HSV-2) infections are sexually transmitted and propagate in sexual networks. Using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which HSV-2 prevalence can be a proxy of HIV prevalence.

Design/methods

An individual-based simulation model was constructed to describe sex partnering and infection transmission, and was parameterized with representative natural history, transmission, and sexual behavior data. Correlations were assessed on model outcomes (HIV/HSV-2 prevalences) and multiple linear regressions were conducted to estimate adjusted associations and effect sizes.

Results

HIV prevalence was one-third or less of HSV-2 prevalence. HIV and HSV-2 p

SUBMITTER: Omori R 

PROVIDER: S-EPMC5508852 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature