Theory and Modeling of RNA Structure and Interactions with Metal Ions and Small Molecules.

ABSTRACT: In addition to continuous rapid progress in RNA structure determination, probing, and biophysical studies, the past decade has seen remarkable advances in the development of a new generation of RNA folding theories and models. In this article, we review RNA structure prediction models and models for ion-RNA and ligand-RNA interactions. These new models are becoming increasingly important for a mechanistic understanding of RNA function and quantitative design of RNA nanotechnology. We focus on new methods for physics-based, knowledge-based, and experimental data-directed modeling for RNA structures and explore the new theories for the predictions of metal ion and ligand binding sites and metal ion-dependent RNA stabilities. The integration of these new methods with theories about the cellul

SUBMITTER: Sun LZ 

PROVIDER: S-EPMC5508874 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature