Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.

ABSTRACT: Regulation of L-type Calcium (Ca²⁺) Channel (LCC) gating is critical to shaping the cardiac action potential (AP) and triggering the initiation of excitation-contraction (EC) coupling in cardiac myocytes. The cyclic nucleotide (cN) cross-talk signaling network, which encompasses the β-adrenergic and the Nitric Oxide (NO)/cGMP/Protein Kinase G (PKG) pathways and their interaction (cross-talk) through distinctively-regulated phosphodiesterase isoenzymes (PDEs), regulates LCC current via Protein Kinase A- (PKA) and PKG-mediated phosphorylation. Due to the tightly-coupled and intertwined biochemical reactions involved, it remains to be clarified how LCC gating is regulated by the signaling network from receptor to end target. In addition, the large number of EC coupling-related phos

SUBMITTER: Zhao CY 

PROVIDER: S-EPMC5508987 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature