GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

ABSTRACT:

Aims/hypothesis

We aimed to investigate potential interactions between insulin and glucagon-like peptide (GLP)-1 signalling pathways in the regulation of beta cell-cycle dynamics in vivo, in the context of the therapeutic potential of GLP-1 to modulate impaired beta cell function.

Methods

Beta cell-specific insulin receptor knockout (βIRKO) mice, which exhibit beta cell dysfunction and an age-dependent decrease in beta cell mass, were treated with the dipeptidyl peptidase-4 inhibitor vildagliptin. Following this, glucose homeostasis and beta cell proliferation were evaluated and underlying molecular mechanisms were investigated.

Results

The sustained elevation in circulating GLP-1 levels, caused by treatment of the knockout mice with vildagliptin for 6 weeks, signific

SUBMITTER: Kawamori D 

PROVIDER: S-EPMC5508991 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature