Neurovascular Cell Sheet Transplantation in a Canine Model of Intracranial Hemorrhage.

ABSTRACT: Cell-based therapy for intracerebral hemorrhage (ICH) has a great therapeutic potential. However, methods to effectively induce direct regeneration of the damaged neural tissue after cell transplantation have not been established, which, if done, would improve the efficacy of cell-based therapy. In this study, we aimed to develop a cell sheet with neurovasculogenic potential and evaluate its usefulness in a canine ICH model. We designed a composite cell sheet made of neural progenitors derived from human olfactory neuroepithelium and vascular progenitors from human adipose tissue-derived stromal cells. We also generated a physiologic canine ICH model by manually injecting and then infusing autologous blood under arterial pressure. We transplanted the sheet cells (cell sheet group) or salin

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC5509018 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature