The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes.

ABSTRACT: Some human populations interbred with Neanderthals and Denisovans, resulting in substantial contributions to modern-human genomes. Therefore, it is now possible to use genomic data to investigate mechanisms that shaped historical gene flow between humans and our closest hominin relatives. More generally, in eukaryotes, mitonuclear interactions have been argued to play a disproportionate role in generating reproductive isolation. There is no evidence of mtDNA introgression into modern human populations, which means that all introgressed nuclear alleles from archaic hominins must function on a modern-human mitochondrial background. Therefore, mitonuclear interactions are also potentially relevant to hominin evolution. We performed a detailed accounting of mtDNA divergence among hominin linea

SUBMITTER: Sharbrough J 

PROVIDER: S-EPMC5509035 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature