Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study.

ABSTRACT:

Objective

To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease.

Methods

A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios.

Results

A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p < 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p < 0.01). After adjustment for potential confounders which have been proposed t

SUBMITTER: Wu MC 

PROVIDER: S-EPMC5509109 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature