Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.

ABSTRACT: Globally, lung cancer results in more deaths worldwide than any other cancer, indicating a need for better treatments. Members of the eicosanoid metabolism pathway represent promising therapeutic targets, as several enzymes involved in the generation of these lipids are dysregulated in many cancers and their inhibition reduces lung cancer growth in mouse models. However, genetic variation of enzymes involved in eicosanoid metabolism has not been adequately examined for association with lung cancer. The goal of this study was to determine whether germline genetic variation altering eicosanoid producing enzyme function and/or expression are associated with differences in lung cancer survival. We examined the association of genetic variation with mortality within eicosanoid metabolism genes i

SUBMITTER: Sausville LN 

PROVIDER: S-EPMC5509150 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature