Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

ABSTRACT:

Background

Changes in microbial community composition in the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures in the human lung associated with CT defined abnormalities is limited.

Methods

Bacterial community composition derived from brush samples from lungs of 16 patients suffering from different CT defined subtypes of COPD and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing of 16S rRNA gene fragment amplicons.

Results

We could show that bacterial community composition in patients with changes in CT (either airway or emphysema type changes, designated as severe subtypes) was different from community composition in lu

SUBMITTER: Engel M 

PROVIDER: S-EPMC5509234 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature