Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance.

ABSTRACT:

Background

Aortic stenosis is the most common age-related valvular pathology. Patients with aortic stenosis and myocardial fibrosis have worse outcome but the underlying mechanism is unclear. Lipoprotein(a) is associated with adverse cardiovascular risk and is elevated in patients with aortic stenosis. Although mechanistic pathways could link Lipoprotein(a) with myocardial fibrosis, whether the two are related has not been previously explored. In this study, we investigated whether elevated Lipoprotein(a) was associated with the presence of myocardial replacement fibrosis.

Methods

A total of 110 patients with mild, moderate and severe aortic stenosis were assessed by late gadolinium enhancement (LGE) cardiovascular magnetic resonance to identify fibrosis. Mann Whitney U test

SUBMITTER: Vassiliou VS 

PROVIDER: S-EPMC5509300 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature