Renal auto-transplantation promotes cortical microvascular network remodeling in a preclinical porcine model.

ABSTRACT: The vascular network is a major target of ischemia-reperfusion, but has been poorly investigated in renal transplantation. The aim of this study was to characterize the remodeling of the renal vascular network that follows ischemia-reperfusion along with the most highly affected cortex section in a preclinical renal transplantation model. There were two experimental groups. The first was a grafted kidney group consisting of large white pigs for which the left kidney was harvested, cold flushed, preserved for 24 h in the University of Wisconsin's preservation solution, and then auto-transplanted (n = 5); the right kidney was removed to mimic the situation of human kidney transplantation. The second group (uni-nephrectomized kidney group) consisted of animals that underwent only right nephre

SUBMITTER: Maiga S 

PROVIDER: S-EPMC5509304 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature