Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.

ABSTRACT:

Objective

To collectively evaluate the association of glucose-6-phosphatase catalytic unit 2 (G6PC2) allele variants with elevated fasting glucose (FG) and type 2 diabetes (T2D).

Design

Meta-analysis.

Data sources

PubMed, Web of Knowledge and Embase databases.

Study selection

Full text articles of studies that identified an association of G6PC2 with T2D and elevated FG.

Patient involvement

There was no T2D patient involvement in the analyses on the association of FG with G6PC2, there were T2D patients and non-diabetes patient involvement in the analyses on the association of T2D with G6PC2.

Statistical analysis

Random-effects meta-analyses were used to calculate the pool effect sizes. I2 metric and H2 tests were used to calculate the heterogeneity

SUBMITTER: Shi Y 

PROVIDER: S-EPMC5509327 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature