Ontology highlight
ABSTRACT:
SUBMITTER: Overacre-Delgoffe AE
PROVIDER: S-EPMC5509332 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell 20170525 6
Regulatory T cells (T<sub>regs</sub>) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is required to maintain intratumoral T<sub>reg</sub> stability and function but is dispensable for peripheral immune tolerance. T<sub>reg</sub>-restricted Nrp1 deletion results in profound tumor resistance due to T<sub>reg</sub> functional fragility. Thus, identifying the basis for Nrp1 dependency and the key drivers of T<sub>reg</sub> fragility could help to improve immunotherapy for human cancer. We ...[more]