IL-10 induces a STAT3-dependent autoregulatory loop in T_H2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

ABSTRACT: Blimp-1 expression in T cells extinguishes the fate of T follicular helper cells, drives terminal differentiation, and limits autoimmunity. Although various factors have been described to control Blimp-1 expression in T cells, little is known about what regulates Blimp-1 expression in T helper 2 (T_H2) cells and the molecular basis of its actions. We report that signal transducer and activator of transcription 3 (STAT3) unexpectedly played a critical role in regulating Blimp-1 in T_H2 cells. Furthermore, we found that the cytokine interleukin-10 (IL-10) acted directly on T_H2 cells and was necessary and sufficient to induce optimal Blimp-1 expression through STAT3. Together, Blimp-1 and STAT3 amplified IL-10 production in T_H2 cells, creating a stron

SUBMITTER: Poholek AC 

PROVIDER: S-EPMC5509416 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature