Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model.

ABSTRACT: Fractures still present a significant burden to patients due to pain and periods of unproductivity. Numerous growth factors have been identified to regulate bone remodeling. However, to date, only the bone morphogenetic proteins (BMPs) are used to enhance fracture healing in clinical settings. Activins are pleiotropic growth factors belonging to the TGF-β superfamily. We and others have recently shown that treatment with recombinant fusion proteins of activin receptors greatly increases bone mass in different animal models by trapping activins and other ligands thus inhibiting their signaling pathways. However, their effects on fracture healing are less known. Twelve-week old male C57Bl mice were subjected to a standardized, closed tibial fracture model. Animals were divided into control a

SUBMITTER: Puolakkainen T 

PROVIDER: S-EPMC5509431 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature