The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Concerns have arisen about the long-term health effects of repeat gadolinium injections in patients with multiple sclerosis and the incomplete characterization of MS lesion pathophysiology that results from relying on enhancement characteristics alone.

Purpose

Our aim was to perform a systematic review and meta-analysis analyzing whether noncontrast MR imaging biomarkers can distinguish enhancing and nonenhancing brain MS lesions.

Data sources

Our sources were Ovid MEDLINE, Ovid Embase, and the Cochrane data base from inception to August 2016.

Study selection

We included 37 journal articles on 985 patients with MS who had MR imaging in which T1-weighted postcontrast sequences were compared with noncontrast sequences obtained during the same MR imagin

SUBMITTER: Gupta A 

PROVIDER: S-EPMC5509500 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature