Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation.

ABSTRACT: BackgroundCD31, expressed by the majority of the neonatal T-cell pool, is involved in modulation of T-cell receptor signaling by increasing the threshold for T-cell activation. Therefore, CD31 could modulate neonatal tolerance and adaptive immune responses.MethodsLymphocytes were harvested from murine neonates at different ages, human late preterm and term cord blood, and adult peripheral blood. Human samples were activated over a 5-day period to simulate acute inflammation. Mice were infected with influenza; lungs and spleens were harvested at days 6 and 9 post infection and analyzed by flow cytometry.ResultsCD31-expressing neonatal murine CD4⁺ and CD8a⁺ T cells increase over the first week of life. Upon in vitro stimulation, human infants' CD4⁺ and CD8a

SUBMITTER: Fike AJ 

PROVIDER: S-EPMC5509503 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature