Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.

ABSTRACT:

Background

Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression.

Methods

Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and

SUBMITTER: Albaugh MD 

PROVIDER: S-EPMC5509516 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature